Presented as a paranormal documentary series titled My Roanoke Nightmare, the story follows a married couple whose experiences are reenacted by actors. Shelby (Lily Rabe) and Matt Miller (André Holland) move from Los Angeles, California, to a house in North Carolina following a brutal assault which left Matt temporarily hospitalized and caused Shelby to have a miscarriage. As soon as the couple settles into their new home, set in the Roanoke Island, strange and paranormal occurrences begin to haunt them and Matt’s sister, Lee Harris (Adina Porter). In the five-episode documentary, Shelby is portrayed by the extravagant English actress Audrey Tindall (Sarah Paulson), Matt by the conceited Dominic Banks (Cuba Gooding Jr.) and Lee by the alcoholic Monet Tumusiime (Angela Bassett).
The leader of Roanoke’s colonists, Thomasin White, known as The Butcher, is potrayed by the schizophrenic actress Agnes Mary Winstead (Kathy Bates), while her son, Ambrose, by Dylan (Wes Bentley). The builder and first owner of the house, Edward Philippe Mott, is played by Rory Monahan (Evan Peters) and the previous owner, before the arrival of the Millers, by William van Henderson (Denis O’Hare).
The second half of the season presents the follow-up series entitled Return to Roanoke: Three Days in Hell, which places the reenactors and their real life counterparts in the Roanoke house for three days during the Blood Moon, designed by My Roanoke Nightmare’s producer Sidney Aaron James (Cheyenne Jackson). The assembled found footage displays how all but one of the participants die as they face the true horrors within the Roanoke house.